Charlie took the pill on Monday and could not even walk this morning. I gave my 10 year old Bull Terrier a dose of Simparico Trio Thursday December 3. He has all the symptoms Eveyone is describing. lola weighs about 9lbs. (Ours never did, she died 4 months later.) Then she started having tremors. One common alternative is to give Heartgard for heartworms and intestinal parasites along with Bravecto to prevent fleas and ticks, but there are other choices out there. We contacted the company using the phone number supplied in the under in the box and shared our experience with the new drug. I have had German Shepherds for 40 yrs. Tick titer came back a light positive which lab said was specifically false due to the recent lyme x2 booster i was scared in to giving. How is your cockapoo doing now? Around 9pm he was barely able to jump up onto the couch and was extremely hesitant to go up the steps. Has anyone's dog broke out with a rash on the belly, I have a miniature schnauzer at her last check up the doctor gave us the simpatico because he no longer sold the topical one I have used for years. 98. Oh how I wish I had know the side effects of this medicine I would never haven given it to her.. the company that makes this poison should be sued. By Sunday he is having liquid diarrhea! Maybe? You can do heartworm no problem, and some flea meds also have a neurology warning but not on the same scale of reports as this tick stuff. She is only 6 and was so full of life and energy. Like other oral treatments, Simparicaworks by entering a dogs bloodstream immediately after ingestion. Is it effective? Hes been on it for six months. Called vet and was advised chicken and rice by tech - vet did not come to the phone even tho I asked to speak to her twice. He has no appetite. She was due to get the next dosage this week and i am choosing not to give it to her with the hopes that it will be out of her system and her Liver levels will go down. Currently we are monitoring him closely-hes never been sick. In addition to the tremors, have you noticed any . He has no appetite, wont drink water and his mouth is so dry. Tuesday morning she woke up with horrible diarrhea. I gave my dog simparica trio. I have an appointment this Wednesday but not sure if Im going to keep it if the cough will go away eventually. Thanks all for sharing your experiences. I feel its from the Simperica trio and will not give it to them ever again. If it was due to the Simparica, then it would expected to be resolved within a day or two. Simparica may show slide side effects in a few dogs like tremors, unsteadiness, and/or seizures but else it is Tested and FDA approved suits to 90% of dogs. Two months no flare up no more scabs and loosing hair. The Vet says it is not the Simparica because he would have vomitted before 9 days. I'll be spreading the word. I'm so sorry. The diarrhea also went away yesterday evening. Also vets needs to tell the truth!!! The very next day he had diarrhea, and had it for 6 days. I gave my 10 month old Yorkie the Simparica Trio dose provided by Banfield when she was spayed. I brought him to the vet and they keep trying to say excessive water drinking isnt a side effect but its the only thing that is different that Ive given my pup. She went on 2 antibiotics, and medicated baths twice a week. We spend last night at the Emergency Vet, and all day today at her normal vet. He is not the same puppy prior to two days ago! She's finally resting at home, but still not able to walk, run, eat, etc. Mine is due for another dose next week and I don't know what to do. For those who lost their dear companions from this medicine my heart goes out to you all. Hopefully there are many other dogs that are unaffected, and just aren't written about here. Since then I've researched loads and as you say the FDA put out a report. Your veterinarian may recommend a heartworm test if you are using Simparica Trio. I have written to the parent company that makes Simparico (although I don't hold high hopes that I will ever hear from them) and also signed an online petition at Change. I gave my dog his first dose the first week of April. I have always used topical tx. I took my dog to the vet today and she received fluids and gabapentin. A heartworm test may be necessary in about six months (that's how long it takes heartworm larvae to mature enough to show up on a test). Thank you for this. They were ok on that but the vet office is no longer going to carry regular Simperica so we took the Simperica trio that is now in its place. I feel like this drug was pushed by my vet tech and veterinarian. But im 99% sure the simparica is what caused it. My Pomeranian is on a steady decline after taking 1 dose. Lone Star, deer, and American and brown dog ticks to prevent up to 15 tick-borne diseases in dogs. And how do we get the word out to everyone? I lost my girl 2 days after taking Simparica. We never thought that there could be a correlation of medication with his anxiety. So you can imagine my worry now. Each month he got sicker and sicker. She has been the healthiest, happiest dog. They are also drinking more than normal. Being in CT where Lyme disease is high it's a relief to have top shelf protection. Could use of Simparica be related to increased prevalence of mast cell tumors in dogs? Some are also approved for treatment and control of ear mite infestations and some gastrointestinal parasite infections, and a few are also approved for prevention of heartworm disease. Guys my heart is racing My 4 month old Aussidoodle (Emma) was just given a Simparica Trio ''treat'', and I was supposed to give it to her today (as she had shots yesterday). (toy aussie & corgi). They still will not consider that it is the Simparica Trio. RELATED: What You Need to Know About the Lyme Vaccine for Dogs. Simparica & Simparica Trio Possible Side Effects This medication is generally well tolerated in most pets. His temp was high and white blood cells elevated. Simparica Trio should be used with caution in dogs with a history of seizures. I never missed a day. He protected our livestock from coyotes for many years and I took good care of him. My 14 year old, 3.5 lb Chihuahua (picture the tan colored Taco Bell Chihuahua, identical) received a tablet that I cut in 4 pieces and buried in his food. He had no medical problems before this, and I took him to the vet every year he ended up dying two weeks later , I took him to the vet first they told me he wasnt gonna make it to leave him there and I told him no if he isnt gonna make it, hes going to pass away in my arms at home with me and his family why took him to a different vet not the same one I confronted the woman that gave me that medicine. When it came time to pick the right product for my own dog, I opted for Simparica Trio. the first puppy was still born looks to have died younger .my assumption when I gave lola that pill.she lost 1 puppy .the second baby is doing okay.although the vet said watch for neurological problems and GI problems. Gave our 6 month old Bulldog puppy Simparica TRIO (this is his 3rd dose) now realizing this is the culprit to what happened with him last month. The doctor did blood work and gave him steroids and said to watch him carefully for the next few days. I am convinced this medicine is HORRIBLE and is causing this. It's been the worst 2 months. Lethargic and confused. I just hope he makes it to his life expectancy . I failed Bentlee this past week and changed to Simparico Trio and now he is having all the same kind of issues. I went home and somthing didn't feel right, but I read the leaflet and it said no known side effects. my puppy was prescribed this and now is weeing more often than usual and still itching ! All they care about is the money and not the animal. We are now 2-3 weeks after our dog's dose of Simparica and are hoping for some improvement in her neurological symptoms as time goes on. The vet just gave our 16lb shorkie this on Tuesday and he still has the tremors really bad and very lethargic, Im very worried and concerned. After spending the day at the ER Vet where they did bloodwork and several x-rays all coming back normal, they sent her home with Keppra. It should be given to your dog once a month and comes in a liver flavor and dogs will likely enjoy the taste. Hi Laura, How is you pup doing one after getting off simparica? The door is open , its where he prefers to sleep on a doggie bed . My 6 year old Chihuahua has been on simparica trio for 4 days . At the same time, it opens glutamate-gated channels, which adds to the flood of nerve communications. Today she has fallen 2 or 3 times in the last 8 hours). My 9-year-old Golden Retriever has been on Simparica for a few years now and not really experiencing any issues. Simparica Trio works to prevent heartworm disease, treat and prevent flea infestations, treat and control tick infestations, and treat and control roundworms and hookworms. 1 is pregnant I told the vet what can I give the pregnant yorkie she said sampirica sold me a 3 month supple for her. He walked outside peed then tried to come back in the house but his legs gave out . She is still in the vet since 3am. According to the FDA, Simparica Trio contains the following active ingredients: "Sarolaner was first approved by the FDA in 2016 to treat and control flea and tick infestations. Im really trying to understand the science behind what is happening to my puppy and the vet, neurologist, drug company have been little help. Get practical pet health tips, articles, and insights from our veterinary community delivered weekly to your inbox. He isnt losing weight but really looks horrible. Wednesday morning at 5am she awoke with bloody diarrhea and it turned into just blood. But he still is suffering from lethargy, polyuria and polydispia basically still drinks and pees non stop. I have spent thousands (around $4500) to get him this care and I'm still in an unknown as to whether he will fully respond to treatment. Then a week later 2 more just 24 hours apart then a little over w week later she had 3 in 24 hours. She's a Brittany (Spaniel). (which I already had read about and did not want to give this prescription to my dog), but so the two nurses at the front desk of my vet continued to say that they prefer simparica. Does anyone know of anything we can give her to help get this out of her system? He has been eating the same organic GF food for the past several years. Humans can get infected with certain intestinal parasites, and fleas sometimes bite people. The following list includes the known side effects of Simparica. He seems sometimes anxious and is sensitive to noise outside. The flea components vary but having had one seizure you're now prone to being sensitive to even the "safer" ones. Our experience with the new drug more scabs and loosing hair eating the same organic GF for... They care about is the money and not the Simparica, then it expected... Dose next week and changed to Simparico Trio Thursday December 3 test if you are using Simparica Trio articles. 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